Chapter 5 of 10
Infection Prevention and Control
Understand how nurses prevent infections and protect patients, themselves, and the healthcare team.
1. Why Infection Prevention and Control Matters
Infection prevention and control (IPC) is a core nursing responsibility. It connects directly to what you learned in:
- Anatomy & Physiology: understanding how pathogens affect body systems (e.g., lungs in pneumonia, urinary tract in UTIs).
- Vital Signs & Bedside Assessment: early changes in temperature, heart rate, respiratory rate, and blood pressure often signal infection.
Why IPC is critical in 2026:
- Healthcare-associated infections (HAIs) still cause significant morbidity, mortality, and cost worldwide.
- COVID-19 (since 2019) highlighted how easily respiratory infections spread in healthcare.
- New and resistant organisms (e.g., MRSA, VRE, ESBL-producing bacteria, C. difficile) continue to emerge.
Nursing roles in IPC:
- Protect patients (especially the very young, elderly, immunocompromised, post-op, and ICU patients).
- Protect yourself and colleagues (occupational health and safety).
- Protect the wider community by preventing spread beyond the facility.
In this module you will:
- Map the chain of infection and see where nursing actions can break it.
- Distinguish standard vs. transmission-based precautions (contact, droplet, airborne).
- Apply hand hygiene and PPE concepts to real clinical scenarios.
2. The Chain of Infection: The Big Picture
The chain of infection describes how infections spread. If you break any link, transmission stops.
Most models include six links:
- Infectious agent – the pathogen (bacteria, virus, fungus, parasite).
- Reservoir – where the pathogen lives and multiplies (people, equipment, water, surfaces).
- Portal of exit – how it leaves the reservoir (coughing, blood, urine, feces, wounds).
- Mode of transmission – how it travels (contact, droplet, airborne, vector, common vehicle).
- Portal of entry – how it enters a new host (mucous membranes, respiratory tract, broken skin, devices).
- Susceptible host – a person with reduced defenses.
Key idea for nurses:
You rarely control the pathogen itself, but you can interrupt transmission at multiple links using:
- Hand hygiene
- PPE
- Safe injection and sharps practices
- Environmental cleaning
- Respiratory hygiene
- Isolation precautions
In the next steps, we’ll walk through each link and connect it to specific nursing actions.
3. Break the Chain: Thought Exercise
Imagine you are caring for a patient with influenza on a medical ward.
Scenario:
- The patient has a fever, cough, and sore throat.
- They cough into their hand, then touch the bed rails and call bell.
- You enter the room to take vital signs.
Your task: For each link in the chain of infection, write down one nursing action to break it.
Use this template in your notes:
```text
- Infectious agent (influenza virus):
- Action:
- Reservoir (patient, contaminated surfaces):
- Action:
- Portal of exit (respiratory secretions):
- Action:
- Mode of transmission (droplets, hands):
- Action:
- Portal of entry (your mucous membranes, other patients):
- Action:
- Susceptible host (roommate, other patients):
- Action:
```
Then compare your ideas with this example solution (don’t peek until you’ve tried):
- Think: Which actions are standard precautions (used for all patients)?
- Which are transmission-based (specific to respiratory infections)?
4. Standard Precautions: Your Everyday Baseline
Standard precautions are the minimum infection prevention practices applied to every patient, every time, regardless of diagnosis or infection status.
Modern guidelines (e.g., CDC, WHO, and many national IPC standards, updated through the COVID-19 era) include:
- Hand hygiene
- Alcohol-based hand rub (ABHR) if hands are not visibly soiled.
- Soap and water when hands are visibly dirty, after caring for patients with known or suspected C. difficile or norovirus, and after restroom use.
- Use of PPE based on risk assessment
- Gloves: when contact with blood, body fluids, mucous membranes, non-intact skin, or contaminated surfaces is likely.
- Gown/apron: when clothing may be exposed to blood/body fluids.
- Mask/eye protection/face shield: when splashes or sprays are possible.
- Respiratory hygiene / cough etiquette
- Encourage covering coughs/sneezes, using tissues, and mask use for symptomatic patients.
- Safe injection practices
- Single-use needles and syringes, aseptic technique, proper sharps disposal.
- Safe handling of equipment and environment
- Clean and disinfect reusable equipment between patients.
- Proper linen and waste management.
- Environmental cleaning and disinfection
- Routine cleaning of high-touch surfaces with approved disinfectants.
Clinical connection:
If you only remember one rule: act as if every patient could have a transmissible infection—because they might, even if not diagnosed yet.
5. Transmission-Based Precautions: Contact, Droplet, Airborne
When standard precautions are not enough, we add transmission-based precautions based on how a pathogen spreads.
1. Contact Precautions
Used for pathogens spread by direct touch or indirect contact via surfaces/equipment.
Examples of conditions:
- MRSA, VRE skin colonization/infection
- C. difficile diarrhea
- Major wound infections
Typical measures (conceptual):
- Single room or cohorting.
- Gloves and gown on room entry.
- Dedicated or disinfected equipment (e.g., stethoscope, BP cuff).
Example:
You’re caring for a patient with C. difficile:
- Perform handwashing with soap and water (ABHR is less effective against spores).
- Wear gloves and gown for any room entry.
- Clean environment with sporicidal disinfectant as per local policy.
---
2. Droplet Precautions
Used for pathogens spread by large respiratory droplets (typically travel ~1–2 meters / 3–6 feet).
Examples of conditions:
- Influenza
- Pertussis (whooping cough)
- Meningococcal meningitis
Typical measures:
- Surgical/medical mask for staff/visitors within close distance.
- Patient wears a mask when leaving the room.
- Single room if possible.
Example:
You take vital signs for a patient with suspected influenza:
- Perform hand hygiene.
- Put on a surgical mask before entering.
- Ask the patient to mask when transported to X-ray.
---
3. Airborne Precautions
Used for pathogens spread via small airborne particles that remain suspended and travel longer distances.
Examples of conditions:
- Pulmonary tuberculosis (TB)
- Measles
- Varicella (chickenpox)
Typical measures:
- Airborne infection isolation room (AIIR / negative pressure room), if available.
- Fit-tested respirator (e.g., N95, FFP2/FFP3, or equivalent) for staff.
- Patient wears a surgical mask when transported.
Example:
You assist with care for a patient with suspected TB:
- Perform hand hygiene.
- Put on fit-tested respirator before entering.
- Keep the door closed to maintain negative pressure.
Important: Specific PPE types and room requirements can vary by country and institutional policy. Always follow your local, up-to-date guidelines.
6. Hand Hygiene: The Most Important Single Action
Hand hygiene is consistently identified as the most effective IPC measure.
When to Perform Hand Hygiene
A widely used framework (WHO "5 Moments for Hand Hygiene"):
- Before touching a patient
- Before clean/aseptic procedures (e.g., IV insertion, catheter care)
- After body fluid exposure risk
- After touching a patient
- After touching patient surroundings
How to Perform Hand Hygiene
Alcohol-based hand rub (ABHR):
- Use when hands are not visibly soiled.
- Apply enough product to cover all hand surfaces.
- Rub all surfaces (palms, backs, between fingers, thumbs, fingertips, wrists) for at least 20–30 seconds, until dry.
Soap and water:
- Use when hands are visibly dirty, after using the toilet, and after caring for patients with C. difficile or norovirus.
- Wet hands, apply soap, rub all surfaces for at least 20 seconds, rinse, dry with a clean towel, and use towel to turn off tap if not hands-free.
Common Pitfalls
- Wearing gloves instead of hand hygiene (you still need hand hygiene before and after glove use).
- Missing the thumbs and fingertips.
- Rushing (less than 20 seconds).
Link to physiology: Remember skin is a barrier organ; damaged or dry skin is more prone to harbor pathogens, so use moisturizer compatible with your facility’s products.
7. PPE Sequencing: Donning and Doffing
Correct order of putting on (donning) and taking off (doffing) PPE reduces self-contamination.
Orders can vary slightly by guideline, but a common, conceptually sound sequence is:
Donning (Putting On PPE)
Try to arrange these steps in the correct order before looking at the answer:
- Gloves
- Gown
- Respirator or mask
- Eye protection (goggles/face shield)
Write your guessed order in your notes.
Now compare to this commonly taught sequence:
```text
- Gown
- Mask or respirator
- Goggles or face shield
- Gloves
```
Doffing (Removing PPE)
Doffing is higher risk because PPE is contaminated.
Try to arrange these steps in a safe order:
- Gloves
- Gown
- Eye protection
- Mask/respirator
Example of a safe sequence:
```text
- Gloves (most contaminated)
- Gown
- Hand hygiene
- Goggles or face shield
- Mask or respirator (after leaving room for airborne, if policy requires)
- Hand hygiene again
```
Reflect:
- Where would you perform hand hygiene in your sequence?
- How might the sequence change slightly based on local policy or specific PPE design?
Always follow your facility’s current donning/doffing posters and training, which may have been updated after COVID-19 experience.
8. Quick Check: Hand Hygiene and PPE
Answer this question to check your understanding of when to use hand hygiene and PPE.
You are about to change a patient’s wound dressing. The wound is draining serous fluid, but there is no visible blood. What is the BEST sequence of actions before you touch the wound?
- Put on gloves, then perform hand hygiene.
- Perform hand hygiene, put on gloves, then put on a gown if there is a risk of splashing.
- Put on a mask and eye protection only, because there is no blood.
- No PPE is needed because it is only serous fluid.
Show Answer
Answer: B) Perform hand hygiene, put on gloves, then put on a gown if there is a risk of splashing.
You should perform hand hygiene BEFORE donning gloves. Then select PPE based on risk assessment: at minimum gloves; add a gown if there is a risk of splashing or soiling clothing. Option 1 has the sequence reversed, and options 3 and 4 underestimate the risk from body fluids other than blood.
9. Putting It Together: Two Short Clinical Scenarios
Scenario A: Postoperative Fever
A 72-year-old patient is 2 days post-op after abdominal surgery. Vital signs:
- Temp: 38.5 °C
- HR: 104 bpm
- RR: 22 breaths/min
- BP: 110/70 mmHg
You notice:
- Surgical dressing is slightly moist at the edges.
- Urinary catheter in place.
IPC-focused thinking:
- Chain of infection: possible reservoir at surgical site or catheter.
- Actions:
- Perform hand hygiene before assessment.
- Use clean gloves when inspecting the wound and handling the catheter.
- Maintain aseptic technique for any dressing change.
- Ensure closed drainage system for catheter; no breaks in the line.
- Educate patient about respiratory hygiene and hand hygiene.
---
Scenario B: Suspected Pulmonary Tuberculosis
A 40-year-old patient presents with chronic cough, weight loss, night sweats, and hemoptysis. TB is suspected.
IPC-focused thinking:
- Mode of transmission: airborne.
- Actions:
- Place patient in an airborne infection isolation room (if available) or follow local TB isolation policy.
- Perform hand hygiene.
- Wear a fit-tested respirator (e.g., N95/FFP2/FFP3) before entering.
- Keep door closed; limit transport and visitors.
- Educate patient to wear a surgical mask when leaving the room for tests.
In both cases, you apply standard precautions plus appropriate transmission-based precautions based on suspected/known pathogens.
10. Review Key Terms
Flip these cards (mentally or with a partner) to reinforce key IPC concepts.
- Standard precautions
- The minimum infection prevention practices applied to ALL patient care, regardless of suspected or confirmed infection status (e.g., hand hygiene, risk-based PPE, respiratory hygiene, safe injection, equipment and environmental cleaning).
- Transmission-based precautions
- Additional infection control measures used for patients with known or suspected infections that are spread by specific routes (contact, droplet, airborne), implemented on top of standard precautions.
- Contact precautions
- Precautions used for infections spread by direct or indirect contact (e.g., MRSA, C. difficile), typically including gloves and gown upon room entry and dedicated/disinfected equipment.
- Droplet precautions
- Precautions for infections transmitted by large respiratory droplets (e.g., influenza), typically including a surgical/medical mask for staff within close distance and masking the patient during transport.
- Airborne precautions
- Precautions for infections transmitted via small airborne particles that remain suspended in air (e.g., TB, measles), typically including a fit-tested respirator and an airborne infection isolation (negative pressure) room when available.
- Chain of infection
- A model describing how infection spreads through six links: infectious agent, reservoir, portal of exit, mode of transmission, portal of entry, and susceptible host.
- Hand hygiene
- The practice of cleaning hands (with alcohol-based hand rub or soap and water) at key moments to remove or kill microorganisms and prevent transmission.
- Personal protective equipment (PPE)
- Equipment worn to reduce exposure to hazards, including gloves, gowns, masks/respirators, eye protection, and face shields, selected based on risk assessment and route of transmission.
Key Terms
- Reservoir
- Any person, animal, substance, or environment in which an infectious agent normally lives and multiplies.
- Hand hygiene
- Cleaning hands with alcohol-based hand rub or soap and water to prevent the spread of microorganisms.
- Contact transmission
- Spread of pathogens through direct physical contact or indirectly via contaminated surfaces or equipment.
- Droplet transmission
- Spread via relatively large respiratory droplets that travel a short distance (typically 1–2 meters) before settling.
- Standard precautions
- Baseline infection prevention measures applied to all patients at all times, regardless of known infection status.
- Airborne transmission
- Spread via small particles that remain suspended in the air and can travel longer distances.
- Transmission-based precautions
- Additional precautions (contact, droplet, airborne) used when a specific route of transmission is known or suspected.
- PPE (Personal protective equipment)
- Protective clothing and devices such as gloves, gowns, masks, respirators, and eye protection used to reduce exposure to infectious agents.
- Healthcare-associated infection (HAI)
- Infection that a patient acquires while receiving care in a healthcare setting, which was not present or incubating at the time of admission.
- Airborne infection isolation room (AIIR)
- A specially engineered room (often negative pressure) designed to prevent airborne pathogens from escaping into surrounding areas.